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The lungs and gas exchange

Organisation · Animal tissues, organs and organ systems · note 9 of 20

The lungs and gas exchangeSpec 4.2.2.2

In short

Gas exchange in the lungs happens at the alveoli. Air passes down the trachea into two bronchi, which branch into tubes ending in alveoli. Oxygen diffuses into the blood in the surrounding capillaries and carbon dioxide diffuses out. Millions of alveoli give a large surface area, and their walls are one cell thick, giving a short diffusion distance.

You need to know the structure of the lungs and how they are adapted for gaseous exchange. Knowledge of the lungs is restricted to the trachea, bronchi, alveoli and the capillary network surrounding the alveoli.

  1. Air passes down the trachea.
  2. The trachea divides into two bronchi, one to each lung.
  3. The bronchi branch into smaller tubes that end in alveoli (air sacs).
  4. At the alveoli, oxygen diffuses into the blood in the surrounding capillaries and carbon dioxide diffuses out of the blood into the air.

Blood arriving at the lungs has a low concentration of oxygen and a high concentration of carbon dioxide. Oxygen therefore diffuses from the air in the alveoli into the blood, and carbon dioxide diffuses the other way.

How the alveoli are adapted for gas exchange
AdaptationWhy it helps
Millions of alveoliGives a very large surface area for diffusion
Walls one cell thickShort diffusion distance, so gases cross quickly
Surrounded by a network of capillaries (a good blood supply)Blood carries oxygen away and brings carbon dioxide, which keeps a steep concentration gradient
Constantly ventilated by breathingFresh air keeps the oxygen concentration high in the alveoli, which also keeps a steep concentration gradient
The trachea dividing into two bronchi that branch and end in alveoli, with a close-up of one alveolus surrounded by a capillary: oxygen diffuses from the alveolus into the blood and carbon dioxide diffuses from the blood into the alveolus. (opens full size in a new tab)
Oxygen diffuses into the blood and carbon dioxide diffuses out across a wall one cell thick.
Exam tip:

In gas exchange answers, link each feature to its effect: ‘thin wall, so short diffusion distance’ earns the mark. Naming the feature alone does not.

Written and checked against the AQA GCSE Combined Science (8464) specification · Updated October 2026

Frequently asked questions

Why do enzymes denature at high temperatures?

At high temperatures the shape of the enzyme's active site changes, so the substrate no longer fits and the reaction cannot be catalysed. The enzyme is denatured, and this cannot be changed back. Below the optimum, the rate rises with temperature because particles move faster and collide more often. Enzymes are not killed, because they are not alive.

How are alveoli adapted for gas exchange?

Millions of alveoli give a very large surface area for diffusion. Their walls are one cell thick, so the diffusion distance is short. A network of capillaries carries oxygen away and brings carbon dioxide, and constant ventilation brings fresh air. Both keep a steep concentration gradient, so oxygen diffuses into the blood and carbon dioxide diffuses out quickly.

Why is the left ventricle thicker than the right?

The left ventricle has a thicker muscular wall than the right because it pumps blood all the way around the body at a higher pressure. The right ventricle only pumps blood to the lungs. Both are part of the double circulatory system, in which blood passes through the heart twice on each complete circuit.

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