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Cells, tissues, organs and organ systems

Organisation · Principles of organisation · note 1 of 2

Cells, tissues, organs and organ systemsSpec 4.2.1

In short

A tissue is a group of cells with a similar structure and function, an organ is an aggregation of tissues performing specific functions, and organs are organised into organ systems. The stomach is an organ: muscular tissue churns food, glandular tissue makes digestive juices and epithelial tissue covers its surfaces. It is part of the digestive system.

Living things are built up in levels. Each level is made from the one below it.

Cell
The basic building block of all living organisms.
Tissue
A group of cells with a similar structure and function.
Organ
An aggregation of tissues performing specific functions.
Organ system
Organs are organised into organ systems, which work together to form organisms.

The stomach is a good example of an organ. It is made of several tissues that work together. Muscular tissue churns the food, glandular tissue makes digestive juices (enzymes and acid), and epithelial tissue covers the inside and outside surfaces.

The stomach is one of the organs in the digestive system. This is an organ system: several organs working together to digest and absorb food.

Levels of organisation
LevelAnimal examplePlant example
CellA muscle cellA palisade mesophyll cell
TissueMuscular tissuePalisade mesophyll
OrganThe stomach or the heartA leaf
Organ systemThe digestive system or the circulatory systemRoots, stem and leaves (transport system)
OrganismA humanA tree
Exam tip:

An organ contains more than one tissue. To explain why something is an organ, say it is made of several tissues that work together to do a specific job.

A staircase showing the levels of organisation: a muscle cell, muscular tissue, the stomach (an organ), the digestive system (an organ system) and a human (an organism). (opens full size in a new tab)
Each level is made from the one below: cell → tissue → organ → organ system → organism.

Written and checked against the AQA GCSE Combined Science (8464) specification · Updated October 2026

Frequently asked questions

What is the difference between a tissue and an organ?

A tissue is a group of cells with a similar structure and function, such as muscular tissue. An organ is an aggregation of several tissues performing specific functions. The stomach is an organ because muscular, glandular and epithelial tissues work together in it: one churns the food, one makes digestive juices and one covers its surfaces.

What are the levels of organisation in biology?

The levels of organisation, from smallest to largest, are cells, tissues, organs, organ systems and the whole organism. Each level is made from the one below it. For example, muscle cells form muscular tissue, which is part of the stomach, an organ in the digestive system. In a plant, a palisade cell is part of a leaf.

What is an organ system?

An organ system is a group of organs that work together, and organ systems work together to form organisms. The digestive system is an example: organs such as the stomach, pancreas and small intestine work together to digest and absorb food. In plants, the roots, stem and leaves form an organ system for transport.

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