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Cell structure — AQA GCSE Combined Science: Trilogy

Eukaryotic and prokaryotic cells, sub-cellular structures, specialised cells, differentiation, and microscopy with magnification calculations.

Spec 4.1.1Cell biology, subtopic 1 of 3

Revision notes

6 short notes, in the order of the specification. Each one in short:

  1. Eukaryotic cells, such as plant and animal cells, have a cell membrane, cytoplasm and genetic material enclosed in a nucleus. Prokaryotic cells, such as bacteria, are much smaller. Their genetic material is not enclosed in a nucleus: it is a single DNA loop, and there may be one or more small rings of DNA called plasmids.

  2. Most animal cells have a nucleus, cytoplasm, a cell membrane, mitochondria and ribosomes. Plant cells have these too, and often also have chloroplasts, which absorb light for photosynthesis, and a permanent vacuole filled with cell sap. Plant and algal cells also have a cell wall made of cellulose, which strengthens the cell.

  3. Required practical 1 uses a light microscope to observe, draw and label plant and animal cells. Mount thin tissue on a slide with water or a stain and a cover slip, focus on the lowest-power objective with the coarse focusing knob, then sharpen with the fine knob. Total magnification is the eyepiece lens magnification multiplied by the objective lens magnification.

  4. A specialised cell has structures that suit it to a particular function. A sperm cell has a tail and many mitochondria to release energy for swimming. A nerve cell is long, with branched connections, to carry impulses. A root hair cell has a long hair-like projection, giving a large surface area to absorb water and mineral ions.

  5. Differentiation is the process by which a cell acquires different sub-cellular structures so that it can carry out a certain function, becoming a specialised cell. Most types of animal cell differentiate at an early stage, but many types of plant cell keep the ability to differentiate throughout life. In mature animals, cell division is mainly for repair and replacement.

  6. An electron microscope uses electrons instead of light, so it has much higher magnification and resolving power than a light microscope. This lets biologists see much finer detail, such as ribosomes and the internal structure of mitochondria and chloroplasts. Magnification is calculated with magnification = size of image ÷ size of real object, using the same units for both.

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Quick check questions

  1. How is the genetic material of a bacterial cell arranged?

    Show answer

    As a single DNA loop that is not enclosed in a nucleus. There may also be plasmids.

  2. Which sub-cellular structure is the site of aerobic respiration?

    Show answer

    Mitochondria.

  3. What is the formula for magnification?

    Show answer

    Magnification = size of image ÷ size of real object.

  4. Why does an electron microscope show more detail than a light microscope?

    Show answer

    It has much higher magnification and resolving power.

  5. Triple only: why are inoculating loops passed through a flame?

    Show answer

    To sterilise them and kill unwanted microorganisms.

Frequently asked questions

What is the difference between prokaryotic and eukaryotic cells?

Eukaryotic cells, such as plant and animal cells, have their genetic material enclosed in a nucleus. Prokaryotic cells, such as bacteria, are much smaller and their genetic material is not in a nucleus. It is a single DNA loop, and there may be plasmids. Both types of cell have a cell membrane and cytoplasm.

Why do plant cells have a cell wall?

Plant cells have a cell wall made of cellulose because it strengthens the cell. Animal cells do not have a cell wall. Plant cells also often have a permanent vacuole filled with cell sap, which helps keep the cell firm, and chloroplasts, which contain chlorophyll to absorb light energy for photosynthesis.

How do you calculate magnification in biology?

Magnification is calculated with magnification = size of image ÷ size of real object. Make sure both measurements are in the same units before you divide. Rearranged, real size = image size ÷ magnification. For a light microscope, the total magnification is the eyepiece lens magnification multiplied by the objective lens magnification.

How are root hair cells adapted to their function?

Root hair cells absorb water and mineral ions from the soil. A long hair-like projection gives a large surface area, and a thin cell wall helps absorption. They have many mitochondria, which release energy from respiration for the active transport of mineral ions from very dilute solutions in the soil.

Written and checked against the AQA GCSE Combined Science (8464) specification · Updated October 2026