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The menstrual cycle

Animal coordination, control and homeostasis · The menstrual cycle and fertility control · note 1 of 5

The menstrual cycleSpec 7.4

In short

The menstrual cycle is a series of changes in a woman that repeats about every 28 days. The uterus lining breaks down in menstruation (days 1 to 5), is repaired and thickens, an egg is released at ovulation around day 14, and the lining is then maintained. Oestrogen repairs the lining and progesterone maintains it.

The menstrual cycle is a series of changes in a woman that repeats about every 28 days. Each cycle, an egg is released from an ovary and the lining of the uterus is prepared in case the egg is fertilised.

Stages of the menstrual cycle (days are approximate)
StageDaysWhat happens
Menstruation1 to 5The lining of the uterus breaks down and is lost through the vagina with blood
Repair5 to 14The uterus lining is repaired and thickens again
OvulationAround 14An egg is released from an ovary
Maintenance14 to 28The lining stays thick, ready for a fertilised egg. If there is no pregnancy it breaks down and the cycle starts again

The roles of two hormones

  • Oestrogen is made in the ovaries. It causes the repair and growth of the uterus lining.
  • Progesterone is made in the ovaries. It maintains the uterus lining.
Maths skill:

When you read a hormone graph, say which day the change happens on and whether the level rises, falls or peaks. Use figures from the axes.

A 28-day timeline divided into menstruation (days 1 to 5), repair (days 5 to 14) and maintenance (days 14 to 28), with ovulation at day 14 and a strip below showing the uterus lining thin after menstruation, thickening during repair and staying thick during maintenance. (opens full size in a new tab)
The stages of the menstrual cycle and how the thickness of the uterus lining changes.

Written and checked against the Edexcel GCSE Combined Science (1SC0) specification · Updated October 2026

Frequently asked questions

What happens during the menstrual cycle?

The menstrual cycle repeats about every 28 days. On days 1 to 5 the uterus lining breaks down and is lost in menstruation. From day 5 to 14 oestrogen repairs the lining and it thickens. An egg is released at ovulation around day 14, then progesterone maintains the lining until day 28, ready for a fertilised egg.

What does FSH do in the menstrual cycle?

Higher tier FSH, released by the pituitary gland, causes an egg to mature in an ovary and stimulates the ovaries to produce oestrogen. As oestrogen rises it inhibits FSH and stimulates the release of LH, which causes ovulation. After ovulation, progesterone inhibits FSH and LH, so no more eggs mature while the uterus lining is maintained.

How do contraceptive pills prevent pregnancy?

Contraceptive pills contain oestrogen, progesterone or both, which keep hormone levels high. This stops eggs maturing, so ovulation does not happen and there is no egg to fertilise. Progesterone also makes the mucus at the cervix thicker, so sperm cannot reach an egg. The pill does not kill sperm or stop sperm being made.

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