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The structure of DNA

Genetics · DNA and the genome · note 1 of 3

The structure of DNASpec 3.4

In short

DNA is a polymer made of repeating units called nucleotides. Each nucleotide has a sugar, a phosphate group and one of four bases. Two strands coil into a double helix and are linked by complementary base pairs, joined by weak hydrogen bonds: adenine (A) pairs with thymine (T), and cytosine (C) pairs with guanine (G).

DNA is a polymer made up of many repeating units called nucleotides. A polymer is a long molecule made of many similar smaller units joined together.

  • DNA is made of two strands coiled to form a double helix.
  • Each nucleotide consists of a sugar and a phosphate group, with one of four different bases attached to the sugar.
  • The two strands are linked by a series of complementary base pairs, joined together by weak hydrogen bonds.
The four bases and how they pair
BasePairs with
Adenine (A)Thymine (T)
Thymine (T)Adenine (A)
Cytosine (C)Guanine (G)
Guanine (G)Cytosine (C)

Because A always pairs with T and C always pairs with G, the base sequence on one strand tells you the sequence on the other. If one strand reads A T G C, the complementary strand reads T A C G.

A DNA double helix, an untwisted section showing complementary base pairs A–T and C–G joined by weak hydrogen bonds, and one nucleotide enlarged to show its phosphate group, sugar and base. (opens full size in a new tab)
DNA is a double helix of nucleotides; the bases pair A with T and C with G, held by weak hydrogen bonds.
Common mistake:

The bonds between the two strands are weak hydrogen bonds. They are between the bases, not between the sugar and phosphate groups.

Written and checked against the Edexcel GCSE Combined Science (1SC0) specification · Updated October 2026

Frequently asked questions

What is the structure of DNA?

DNA is a polymer made of nucleotides, with two strands coiled to form a double helix. Each nucleotide has a sugar, a phosphate group and one of four bases. The strands are linked by complementary base pairs, adenine with thymine and cytosine with guanine, held together by weak hydrogen bonds.

What is the difference between a gene and a genome?

A gene is a short section of DNA that codes for a specific protein, while the genome is the entire DNA of an organism. The genome includes all of the organism's genes. Each gene has a different sequence of bases, so each one codes for a different protein.

Why is salt added when extracting DNA from fruit?

Salt is added when extracting DNA from fruit because it helps the DNA clump together. Detergent is added with it to break down the cell membranes and nuclear membranes, so the DNA is released. After filtering, ice-cold ethanol is added, and the DNA comes out of solution as white, stringy strands.

All 4 questions on DNA and the genome