The development of understanding of genetics and evolution — AQA GCSE Biology
Darwin, Wallace and Mendel, evidence for evolution, fossils, extinction and antibiotic-resistant bacteria.
Darwin, Wallace and Mendel, evidence for evolution, fossils, extinction and antibiotic-resistant bacteria.
7 short notes, in the order of the specification. Each one in short:
The theory of evolution by natural selection states that individuals in a species vary, that those with characteristics most suited to the environment are more likely to survive to breed, and that these characteristics are passed on. It was only gradually accepted because it challenged religious belief, evidence was insufficient and the mechanism of inheritance was unknown.
Speciation is the formation of new species. A population becomes isolated, for example by a geographical barrier, so the groups cannot interbreed. Mutations cause genetic variation, and natural selection acts differently in each environment over many generations. Eventually the populations are so different in phenotype that they can no longer interbreed to produce fertile offspring, forming two new species.
Gene theory states that characteristics are inherited through genes located on chromosomes. In the mid-19th century, breeding experiments on plants showed that each characteristic is determined by units passed on unchanged. Later, chromosome behaviour during cell division was observed, these units were linked to chromosomes in the early 20th century, and DNA structure was determined in the mid-20th century.
The evidence for evolution by natural selection comes from three main sources. It has been shown that characteristics are passed on to offspring in genes. The fossil record shows how organisms have changed over time. Antibiotic resistance in bacteria shows natural selection happening in a short time. This evidence is why the theory is now widely accepted.
Fossils are the remains of organisms from millions of years ago, found in rocks. They form from parts of organisms that have not decayed, from parts replaced by minerals as they decay, or as preserved traces such as footprints and burrows. The fossil record is incomplete because many early life forms were soft-bodied and geological activity destroyed most traces.
Extinction occurs when there are no remaining individuals of a species still alive. Factors that may contribute include a change to the environment over geological time, new predators, new diseases, new, more successful competitors, and a single catastrophic event, such as a massive volcanic eruption or an asteroid collision. Each can reduce numbers until none are left.
Antibiotic-resistant bacteria are strains that are not killed by antibiotics, such as MRSA. Bacteria evolve rapidly because they reproduce at a fast rate. A mutation produces a resistant strain. When antibiotics are used, non-resistant bacteria are killed but resistant ones survive and reproduce, so the resistant strain spreads. Appropriate prescribing and completing the course of antibiotics slow this down.
6 exam-style questions (20 marks), each with its mark scheme.
Answer the questions15 cards: flip them, mark what you knew, and practise the rest.
Practise the cardsThe whole of inheritance, variation and evolution on one page, so you can see where this subtopic fits.
Open the mind mapFree PDFs to print or save.
Triple only Give two reasons why Darwin's theory was only gradually accepted.
Any two of: it challenged the idea that God made all animals and plants; there was insufficient evidence; the mechanism of inheritance was not known.
Triple only Who published joint writings with Darwin in 1858?
Alfred Russel Wallace.
Why is the fossil record incomplete?
Early life was soft-bodied and left few traces, and many traces were destroyed by geological activity.
Why do resistant strains of bacteria spread so quickly?
Bacteria reproduce quickly, people are not immune and there is no effective treatment.
Give one way to reduce the development of antibiotic resistance.
Do not prescribe antibiotics inappropriately, complete the course, or restrict agricultural use.
Triple only The theory of evolution by natural selection was only gradually accepted for three reasons. It challenged the idea that God made all the animals and plants that live on Earth, there was insufficient evidence at the time to convince many scientists, and the mechanism of inheritance and variation was not known until 50 years after the theory was published.
The evidence for evolution includes the fossil record, which shows how much or how little organisms have changed as life developed on Earth, the discovery that characteristics are passed on to offspring in genes, and antibiotic resistance in bacteria, which shows natural selection happening in a short time. This is why the theory is now widely accepted.
Fossils form in three ways: from parts of organisms that have not decayed because one or more of the conditions needed for decay are absent, from parts that are replaced by minerals as they decay, or as preserved traces such as footprints, burrows and rootlet traces. Fossils are found in rocks and show how organisms have changed.
Antibiotic resistance develops by natural selection. A mutation produces a strain of bacteria that is resistant to antibiotics. When antibiotics are used, non-resistant bacteria are killed but the resistant bacteria survive and reproduce, so the resistant population rises. Because bacteria reproduce at a fast rate, resistant strains such as MRSA can spread quickly, with no effective treatment.
A species becomes extinct when there are no remaining individuals still alive. Causes include a change to the environment over geological time, new predators, new diseases, new, more successful competitors, and a single catastrophic event such as a massive volcanic eruption or an asteroid collision. Each factor can reduce numbers until none are left.
Written and checked against the AQA GCSE Biology (8461) specification · Updated October 2026