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Assisted reproductive technology

Animal coordination, control and homeostasis · The menstrual cycle and fertility control · note 5 of 5

Spec 7.8
Higher tier (what this means)Higher tier: only on the Higher tier papers. Foundation students can skip it. What the labels mean
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Assisted reproductive technologySpec 7.8

In short

Assisted reproductive technology uses hormones to help people who find it hard to have a baby. In IVF, the woman is given FSH and LH so several eggs mature; the eggs are collected, fertilised by sperm in a dish, and one or two embryos are placed in her uterus. Clomifene stimulates the release of FSH and LH so ovulation happens.

Assisted Reproductive Technology (ART) helps people who find it hard to have a baby. Hormones are used in two types of treatment.

IVF (in vitro fertilisation)

  1. The woman is given FSH and LH. These make several eggs mature in her ovaries.
  2. The eggs are collected from the ovaries.
  3. The eggs are mixed with sperm in a dish in the laboratory, where they are fertilised.
  4. The fertilised eggs develop into embryos.
  5. One or two embryos are placed into the woman's uterus.

Clomifene therapy

Clomifene is a drug taken by women who do not ovulate. It stimulates the release of FSH and LH, so eggs mature and ovulation happens.

Exam tip:

In IVF the hormones are given to make eggs mature. The fertilisation then happens outside the body. Keep these two ideas separate.

Quick check

  1. Which hormone repairs the uterus lining and which maintains it?

    Show answer

    Oestrogen repairs it. Progesterone maintains it.

  2. Around which day does ovulation happen in a 28-day cycle?

    Show answer

    Around day 14.

  3. State one way the contraceptive pill prevents pregnancy.

    Show answer

    It stops ovulation, or thickens the mucus at the cervix so sperm cannot get through.

  4. Give one advantage of condoms over the pill.

    Show answer

    They protect against sexually transmitted infections.

  5. What does clomifene do? (Higher)

    Show answer

    It stimulates the release of FSH and LH so that ovulation happens.

Written and checked against the Edexcel GCSE Biology (1BI0) specification · Updated October 2026

Frequently asked questions

What happens during the menstrual cycle?

The menstrual cycle repeats about every 28 days. On days 1 to 5 the uterus lining breaks down and is lost in menstruation. From day 5 to 14 oestrogen repairs the lining and it thickens. An egg is released at ovulation around day 14, then progesterone maintains the lining until day 28, ready for a fertilised egg.

What does FSH do in the menstrual cycle?

Higher tier FSH, released by the pituitary gland, causes an egg to mature in an ovary and stimulates the ovaries to produce oestrogen. As oestrogen rises it inhibits FSH and stimulates the release of LH, which causes ovulation. After ovulation, progesterone inhibits FSH and LH, so no more eggs mature while the uterus lining is maintained.

How do contraceptive pills prevent pregnancy?

Contraceptive pills contain oestrogen, progesterone or both, which keep hormone levels high. This stops eggs maturing, so ovulation does not happen and there is no egg to fertilise. Progesterone also makes the mucus at the cervix thicker, so sperm cannot reach an egg. The pill does not kill sperm or stop sperm being made.

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