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The work of Darwin and Wallace

Natural selection and genetic modification · Darwin, natural selection and antibiotic resistance · note 1 of 3

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In short

The theory of evolution by natural selection was developed by two scientists working separately, each using their own observations and collections of plants and animals. Their observations included variation within species and organisms suited to their different environments. The theory gives a unifying explanation for the diversity of living things and helps explain antibiotic-resistant bacteria.

The theory of evolution by natural selection was developed by two scientists working separately: Charles Darwin and Alfred Wallace.

Charles Darwin

  • Darwin collected observations and specimens on a long sea voyage, including studying plants and animals in different places.
  • He noticed that individuals of the same species show variation, and that organisms in different places are suited to their different environments.
  • He spent many years collecting evidence and developing his ideas before publishing them in his book On the Origin of Species in 1859.

Alfred Wallace

  • Wallace independently developed a very similar theory of evolution by natural selection.
  • His ideas were based on his own observations and collections of plants and animals in different parts of the world.
  • His work encouraged Darwin to publish, and the two men's ideas were presented together.

Impact on modern biology

  • Natural selection gave a unifying explanation for the huge diversity of living things and how species are related.
  • When combined with later knowledge of genes, it explains how variation arises (through mutation) and how characteristics are inherited.
  • It helps us understand the emergence of resistant organisms, such as antibiotic-resistant bacteria.
  • It supports the idea that living things can be classified according to how they are related.
Exam tip:

If asked about Wallace, say he developed the theory independently of Darwin. Do not say he copied or helped Darwin write the book.

Written and checked against the Edexcel GCSE Biology (1BI0) specification · Updated October 2026

Frequently asked questions

What are the 4 stages of natural selection?

The four stages of natural selection are variation, competition, survival and inheritance. Individuals show variation in their alleles, caused by mutation. More offspring are born than can survive, so they compete. Those best suited to their environment survive and reproduce, then pass on their advantageous alleles, which become more common over generations.

How does natural selection lead to evolution?

Natural selection leads to evolution because individuals with advantageous characteristics are more likely to survive, reproduce and pass on their alleles. In each generation, the proportion of the population with those alleles increases. Over many generations this changes the inherited characteristics of the population, and that change is evolution.

How do bacteria become resistant to antibiotics?

Bacteria become resistant to antibiotics through mutation and natural selection. A random mutation gives one bacterium an allele for resistance. The antibiotic kills the non-resistant bacteria, but the resistant one survives, reproduces with less competition and passes on the allele. Antibiotics do not cause the mutation; they select the resistant bacteria.

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