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Homeostasis — Cambridge IGCSE Biology

Homeostasis and negative feedback, control of blood glucose, treating Type 1 diabetes and temperature control by the skin.

Spec 14.4Coordination and response, subtopic 4 of 5

Revision notes

4 short notes, in the order of the specification. Each one in short:

  1. Homeostasis is the maintenance of a constant internal environment, such as body temperature and blood glucose concentration. It is controlled by negative feedback. When a level moves away from its set point, receptors detect the change and effectors act to reverse it, so the level returns towards the set point. The response then reduces or stops.

  2. Blood glucose concentration is controlled by hormones from the pancreas acting on the liver. Insulin decreases blood glucose: it is secreted when glucose is too high, and the liver converts glucose to glycogen and stores it. Glucagon is secreted when glucose is too low, and the liver converts glycogen back to glucose and releases it into the blood.

  3. Type 1 diabetes

    Supplement

    Type 1 diabetes is a condition in which the pancreas produces little or no insulin, so blood glucose concentration rises after a meal and stays too high. It is treated with insulin injections, usually at mealtimes, by monitoring blood glucose to give the right dose, and by managing the diet, especially the amount of carbohydrate eaten.

  4. Temperature control keeps human body temperature constant at about 37 °C, coordinated by the brain. When too hot, sweat evaporates and takes heat from the body, and vasodilation widens the arterioles supplying skin surface capillaries so more heat is lost. When too cold, shivering releases heat, vasoconstriction reduces blood flow near the surface, and raised hairs trap insulating air.

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Quick check questions

  1. What is homeostasis?

    Show answer

    The maintenance of a constant internal environment.

  2. What does insulin do to blood glucose concentration?

    Show answer

    It decreases it.

  3. Supplement What is a set point?

    Show answer

    The normal level of a factor that the body keeps steady by negative feedback.

  4. Supplement What does the liver do with glucose when insulin is secreted?

    Show answer

    Converts it to glycogen for storage.

  5. Supplement What happens to the arterioles supplying the skin surface capillaries when the body is too cold?

    Show answer

    They narrow (vasoconstriction).

Frequently asked questions

How does the body control blood glucose levels?

Supplement The body controls blood glucose using two hormones from the pancreas that act on the liver. When blood glucose is too high, insulin is secreted and the liver converts glucose to glycogen to store it. When it is too low, glucagon is secreted and the liver converts glycogen to glucose and releases it into the blood.

What does insulin do to blood sugar?

Insulin decreases the blood glucose concentration. It is a hormone secreted by the pancreas when blood glucose is too high, for example after a meal containing carbohydrate. Insulin acts on the liver, which converts glucose into glycogen and stores it, so the concentration of glucose in the blood falls back towards normal.

How is body temperature regulated?

Supplement Body temperature is regulated by the brain, which compares body temperature with the set point and coordinates effectors. When too hot, sweating and vasodilation increase heat loss. When too cold, shivering releases heat by respiration, vasoconstriction reduces blood flow near the skin surface, and raised hairs and fatty tissue provide insulation.

What is negative feedback?

Supplement Negative feedback is the way homeostasis keeps a factor close to its set point. When the level moves away from the set point, receptors detect the change and effectors act to reverse it. When the level is back at the set point, the response is reduced or stops. The level goes slightly above and below the set point.

How is Type 1 diabetes treated?

Supplement Type 1 diabetes is treated with insulin injections, usually at mealtimes, to lower the blood glucose concentration. Blood glucose is monitored so the right dose can be given, and the diet is managed, especially the amount of carbohydrate eaten. Insulin is injected because it is a protein and would be digested if swallowed.

Written and checked against the Cambridge IGCSE Biology (0610) specification · Updated October 2026